What severe, life-threatening condition can occur in individuals with G6PD deficiency upon consuming broad beans?

Answer

Favism, which causes acute, life-threatening hemolysis (destruction of red blood cells)

For individuals genetically predisposed with Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the consumption of broad beans—or even inhalation of their pollen—presents a grave, life-threatening hazard. This specific interaction triggers a condition known as favism. Favism is characterized by acute hemolysis, meaning the rapid and widespread destruction of red blood cells. This massive breakdown of erythrocytes leads to severe complications. Due to this potent, genetically linked risk, strict avoidance of broad beans in all states (fresh, dried, or processed) is mandatory for anyone diagnosed with G6PD deficiency, a condition noted to primarily affect populations descended from Mediterranean, African, and Asian regions.

What severe, life-threatening condition can occur in individuals with G6PD deficiency upon consuming broad beans?

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