What sensory neuron receptor does capsaicin activate to initiate thermogenesis?
Answer
TRPV1
The process by which consuming hot peppers increases the body's heat generation rate, known as thermogenesis, begins with capsaicin binding to a specific sensory neuron receptor called TRPV1. This receptor is normally activated by actual painful heat or physical irritation. When capsaicin binds to TRPV1, it mimics this high-heat signal, tricking the nervous system into triggering thermogenesis, which elevates energy expenditure and contributes to the potential for calorie burning. This same receptor activation is also central to capsaicin's role in pain management through subsequent desensitization.
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