Topical capsaicin's analgesic effect is achieved partly by depleting nerves of which pain-signal neurotransmitter?
Answer
Substance P
When capsaicin is applied topically, it initially overstimulates the targeted nerve endings, causing initial discomfort. Following this intense stimulation, the nerves become desensitized. A key part of this desensitization mechanism involves the depletion of Substance P, which is a crucial neurotransmitter responsible for transmitting pain signals from the site of injury or irritation up to the brain. By depleting the supply of Substance P available in those nerve endings, the intensity of chronic pain signaling is significantly reduced, leading to a dulling effect.
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