What potent neurotoxin is concentrated in the organs of Pufferfish (Fugu)?

Answer

Tetrodotoxin

Pufferfish, famously known as fugu in Japanese culinary contexts, harbors tetrodotoxin, a powerful neurotoxin. This toxin is critically concentrated within the internal organs, particularly the liver and ovaries of the fish. Ingestion of even trace amounts of this substance can rapidly precipitate severe consequences, including paralysis and respiratory distress, often leading to death within a few hours. Because this inherent toxicity is unaffected by standard mitigation processes like freezing or high heat cooking, its preparation is strictly regulated and reserved only for highly trained and licensed chefs capable of meticulously removing the poisonous parts.

What potent neurotoxin is concentrated in the organs of Pufferfish (Fugu)?
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