Which Short-Chain Fatty Acid (SCFA) acts as the main energy source for cells lining the colon?
Answer
Butyrate
Butyrate is one of the Short-Chain Fatty Acids (SCFAs) produced when inulin ferments in the large intestine and colon. Among the SCFAs generated, butyrate holds a particularly vital function as it serves as the principal energy source required by the cells that form the lining of the colon. Furthermore, butyrate plays an important role in regulating cell differentiation within that tissue. The other SCFAs mentioned, like propionate, are also important, but butyrate is specifically highlighted for fueling the colonocytes.
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