How do the Isothiocyanates (ITCs) found in wasabi potentially interfere with the development and progression of tumors according to laboratory studies?

By influencing Phase II detoxification enzymes and inducing apoptosis.

Research into wasabi's cancer defense potential centers on two key mechanisms related to the ITCs. First, these compounds possess the ability to influence Phase II detoxification enzymes within the body. These enzymes are critical for neutralizing and eliminating various carcinogens and harmful substances, effectively helping the body clear out potential threats before they cause damage. Second, studies have indicated that the ITCs can actively trigger programmed cell death, a process known as apoptosis, in various cancer cell lines. This suggests a direct interaction where the active components encourage malignant cells to self-destruct, although it is crucial to remember this is based on lab results and not a proven cure in humans.