How does capsaicin interact with pain receptors over time?
Answer
It desensitizes the nerves that transmit pain signals
Capsaicin exerts a notable effect on the nervous system regarding pain perception. Although initial consumption or topical application causes a burning sensation due to interaction with pain receptors, sustained or repeated exposure leads to a desensitizing effect on those same nerves responsible for sending pain signals to the brain. This mechanism of nerve fatigue or desensitization is the fundamental reason why capsaicin-containing products are frequently formulated into topical creams to provide temporary relief from chronic types of discomfort, such as those stemming from neuropathy or arthritis.
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