What enzyme required for alcohol breakdown is suggested to be inhibited by compounds found in durian, leading to acetaldehyde accumulation when consumed with alcohol?
Answer
Aldehyde dehydrogenase
A significant caution regarding durian consumption involves its interaction with alcohol. Some research indicates that certain compounds within the durian fruit possess the ability to inhibit aldehyde dehydrogenase. This enzyme is absolutely necessary in the metabolic pathway responsible for breaking down acetaldehyde, a toxic byproduct created when the body metabolizes alcohol. When this enzyme is inhibited, acetaldehyde accumulates in the system, leading to unpleasant and potentially serious symptoms such as nausea, discomfort, and flushing. This mechanism highlights a genuinely dangerous interaction that requires consumers to exercise caution.
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