What critical caution did studies assessing the toxicity of the Telfairia occidentalis root extract highlight?

Moderate toxicity at very high concentrations (LD50 approximately 3200 mg/kg)

While much of the focus remains on the nutritionally dense leaves and seeds, research has explored other plant parts, including the root, which contains high levels of minerals like Magnesium and Iron. However, toxicity assessments conducted on the root extract revealed a need for cautious consumption regarding quantity. The studies indicated that moderate toxicity manifested only at very high concentrations, with a specific Lethal Dose 50% (LD50) value cited at approximately 3200 mg/kg. This finding strongly advises maintaining focus on the traditionally consumed parts, such as the leaves and seeds, for safe and consistent dietary intake, rather than large quantities of unprocessed root material.