What active substances are isothiocyanates derived from, aiding detoxification?

Glucosinolates

A key component contributing to the protective nature of cruciferous vegetables like broccolini is the presence of glucosinolates. These are sulfur-containing compounds that are stored within the plant's tissues. When the vegetable is subjected to physical breakdown, such as chewing or chopping, the cellular structure is disrupted, releasing an enzyme (myrosinase) that interacts with the glucosinolates. This enzymatic reaction causes the glucosinolates to break down into various active metabolites, most notably isothiocyanates. These resulting isothiocyanates are biologically significant because they are recognized for having potent anti-cancer properties, primarily by actively supporting and enhancing the body's innate detoxification pathways and processes, helping to neutralize harmful substances.