In the acidic environment of the stomach, what metabolite does Indole-3-Carbinol (I3C) commonly convert into?
Answer
3,3′-diindolylmethane (DIM)
Indole-3-Carbinol (I3C) is another key bioactive compound derived from the glucosinolate glucobrassicin found in broccoli. When I3C is consumed and subsequently enters the highly acidic environment of the stomach, it undergoes a chemical transformation. This transformation results in the formation of 3,3′-diindolylmethane, commonly abbreviated as DIM. Both I3C and its metabolite, DIM, are acknowledged for their anti-inflammatory properties. They exert this effect through overlapping mechanisms with SFN, notably by activating the Nrf2 signaling pathway, while also actively inhibiting the pro-inflammatory NF-κB pathway, contributing significantly to the vegetable’s overall disease protection profile.
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