In mice with induced paw swelling, what mediator did carvacrol diminish while boosting $\text{IL-10}$?

Answer

$\text{PGE}_2$

Carvacrol, a primary component in some oregano oils, demonstrates significant potential in managing inflammatory conditions through a balancing mechanism within the immune response. In experimental models utilizing mice that were induced to have paw swelling, carvacrol was observed to actively reduce the levels of pro-inflammatory mediators. Specifically, it diminished mediators such as $ ext{IL-1}eta$ and Prostaglandin $ ext{E}_2$ ($ ext{PGE}_2$). Simultaneously, this beneficial action was coupled with an increase in the production of the anti-inflammatory cytokine $ ext{IL-10}$. This dual action—suppressing detrimental inflammatory signals while enhancing protective ones—makes carvacrol a compound of significant interest for systemic inflammation management.

In mice with induced paw swelling, what mediator did carvacrol diminish while boosting $\text{IL-10}$?

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