How does the lectin **tarin** modulate the immune response by affecting the inflammatory mediator $ ext{PGE}_2$ to exert its anti-inflammatory action?

Answer

It down-regulates the expression of cyclooxygenase-2 ($ ext{COX}-2$).

Tarin, identified as a specific lectin in taro, exhibits significant antitumoral and immunomodulatory effects. Its anti-inflammatory action is achieved through a specific molecular pathway related to inflammatory mediators. Tarin modulates the immune response by actively reducing the release of prostaglandin E2 ($ ext{PGE}_2$), which is known to promote tumor growth and suppress the immune system's ability to combat cancer. The text specifies that tarin accomplishes this reduction by down-regulating the expression of cyclooxygenase-2, commonly known as $ ext{COX}-2$. $ ext{COX}-2$ is the enzyme responsible for producing $ ext{PGE}_2$, making its down-regulation a key mechanism by which tarin supports immune function and controls tumorigenesis.

How does the lectin **tarin** modulate the immune response by affecting the inflammatory mediator $ ext{PGE}_2$ to exert its anti-inflammatory action?

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