Which specific pro-inflammatory signaling molecules are suppressed by Sabinene hydrate in cellular models?

TNF-$\\alpha$ and IL-1$\\beta$.

Marjoram demonstrates anti-inflammatory potential by actively interfering with the body’s signaling mechanisms responsible for initiating and perpetuating swelling and pain. Specifically, components found in the essential oil, such as sabinene hydrate and terpineol, have been shown in cellular studies to actively suppress the production of key pro-inflammatory signaling molecules. These targeted molecules are Tumor Necrosis Factor-alpha (TNF-$\\alpha$) and Interleukin-1 beta (IL-1$\\beta$). By inhibiting the creation of these specific cytokines, marjoram helps to dampen the systemic inflammatory cascade, which is the underlying mechanism providing relief for conditions associated with internal swelling.