In preclinical studies targeting obesity, which master regulator of fat cell development was shown to have its expression reduced by *A. quinata* extracts, inhibiting adipogenesis?
Answer
PPAR$\\gamma$
The anti-obesity mechanism demonstrated in cellular and animal models involved the targeted suppression of *adipogenesis*, which is the differentiation process where preadipocytes become mature fat-storing cells. This suppression was mechanistically linked to the regulation of key molecular switches governing this development. Specifically, the research noted that the extracts reduced the expression of master regulators, including Peroxisome proliferator-activated receptor-gamma (PPAR$\\gamma$) and CCAAT-enhancer-binding protein alpha (C/EBP$\\alpha$). Inhibiting PPAR$\\gamma$ is a common strategy to block the cellular commitment to becoming a functional adipocyte.
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