What distinguished the goal of ULGCS research from historical attempts to use cottonseed?

Answer

To engineer the seed to produce little to no toxin in the first place

The major scientific innovation involved breeding new cotton varieties where the gossypol levels are inherently low in the seed itself, rather than relying solely on post-extraction refinement.

What distinguished the goal of ULGCS research from historical attempts to use cottonseed?
Safetyhumanmealconsumptioncottonseed